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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
24/06/2019 |
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Actualizado : |
16/03/2021 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
CASAL, A.; GARCÍA-ROCHE, M.; NAVAJAS, E.; CASSINA, A.; CARRIQUIRY, M |
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Afiliación : |
A. CASAL, Departamento de Produccion Animal y Pasturas, Facultad de Agronomia, Universidad de la Republica, Paysandú, Uruguay.; M. GARCÍA-ROCHE, Departamento de Produccion Animal y Pasturas, Facultad de Agronomia, Universidad de la Republica, Montevideo, Uruguay; Center for Free Radical and Biomedical Research (CEINBIO); ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; A. CASSINA, Center for Free Radical and Biomedical Research (CEINBIO) and Departamento de Bioquímica, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay; M. CARRIQUIRY, Departamento de Produccion Animal y Pasturas, Facultad de Agronomia, Universidad de la Republica, Montevideo, Uruguay. |
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Título : |
Differential hepatic oxidative status in steers with divergent residual feed intake phenotype. |
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Fecha de publicación : |
2020 |
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Fuente / Imprenta : |
Animal, 1 January 2020, Volume 14, Issue 1, Pages 78-85. Doi: https://doi.org/10.1017/S1751731119001332 |
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DOI : |
10.1017/S1751731119001332 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 December 2018 // Accepted 6 May 2019 // Published online: 20 June 2019.
Supplementary materials.
Corresponding author: Casal, A.; Departamento de Produccion Animal y Pasturas, Facultad de Agronomia, Universidad de la Republica, Ruta 3 km 363, Paysandu, Uruguay; email:alcas@adinet.com.uy |
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Contenido : |
ABSTRACT.
Oxidative stress occurs when oxidant production exceeds the antioxidant capacity to detoxify the reactive intermediates or to repair the resulting damage. Feed efficiency has been associated with mitochondrial function due to its impact on cell energy metabolism. However, mitochondria are also recognized as a major source of oxidants. The aim of this study was to determine lipid and protein oxidative stress markers, and gene and protein expression as well as activity of antioxidant enzymes in the liver of steers of divergent residual feed intake (RFI) phenotypes. Hereford steers (n = 111) were evaluated in post-weaning 70 days standard test for RFI. Eighteen steers exhibiting the greatest (n = 9; high-RFI) and the lowest (n = 9; low-RFI) RFI values were selected for this study. After the test, steers were managed together under grazing conditions until slaughter when they reached the slaughter body weight. At slaughter, hepatic samples were obtained, were snap-frozen in liquid nitrogen and stored at −80°C until analyses. Hepatic thiobarbituric acid reactive species and protein carbonyls were greater (P = 0.05) and hepatic 4-hydroxynonenal protein adducts tended (P = 0.10) to be greater for high- than low-RFI steers. Hepatic gene expression glutathione peroxidase 4, glutamate?cysteine ligase catalytic subunit and peroxiredoxin 5 mRNA was greater (P ≤ 0.05) and glutathione peroxidase 3 mRNA tended (P = 0.10) to be greater in low- than high-RFI steers. Hepatic protein expression and enzyme activity of manganese superoxide dismutase and glutathione peroxidase enzyme activity tended (P ≤ 0.10) to be greater for low- than high-RFI steers. High-efficiency steers (low-RFI) probably had better hepatic oxidative status which was strongly associated with greater antioxidant ability near to the oxidant production site and, therefore, reduced oxidative stress of the liver. Decreased hepatic oxidative stress would reduce maintenance requirements due to a lower protein and lipid turnover and better efficiency in the use of energy.
© The Animal Consortium 2019 MenosABSTRACT.
Oxidative stress occurs when oxidant production exceeds the antioxidant capacity to detoxify the reactive intermediates or to repair the resulting damage. Feed efficiency has been associated with mitochondrial function due to its impact on cell energy metabolism. However, mitochondria are also recognized as a major source of oxidants. The aim of this study was to determine lipid and protein oxidative stress markers, and gene and protein expression as well as activity of antioxidant enzymes in the liver of steers of divergent residual feed intake (RFI) phenotypes. Hereford steers (n = 111) were evaluated in post-weaning 70 days standard test for RFI. Eighteen steers exhibiting the greatest (n = 9; high-RFI) and the lowest (n = 9; low-RFI) RFI values were selected for this study. After the test, steers were managed together under grazing conditions until slaughter when they reached the slaughter body weight. At slaughter, hepatic samples were obtained, were snap-frozen in liquid nitrogen and stored at −80°C until analyses. Hepatic thiobarbituric acid reactive species and protein carbonyls were greater (P = 0.05) and hepatic 4-hydroxynonenal protein adducts tended (P = 0.10) to be greater for high- than low-RFI steers. Hepatic gene expression glutathione peroxidase 4, glutamate?cysteine ligase catalytic subunit and peroxiredoxin 5 mRNA was greater (P ≤ 0.05) and glutathione peroxidase 3 mRNA tended (P = 0.10) to be greater in low- than high-RFI steers. Hep... Presentar Todo |
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Palabras claves : |
ANTIOXIDANTS; ENERGY METABOLISM; FEED EFFICIENCY; FEEDING; LIVER; OXIDATIVE STRESS. |
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Thesagro : |
ALIMENTACION ANIMAL. |
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Asunto categoría : |
L02 Alimentación animal |
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Marc : |
LEADER 03260naa a2200277 a 4500
001 1059875
005 2021-03-16
008 2020 bl uuuu u00u1 u #d
024 7 $a10.1017/S1751731119001332$2DOI
100 1 $aCASAL, A.
245 $aDifferential hepatic oxidative status in steers with divergent residual feed intake phenotype.$h[electronic resource]
260 $c2020
500 $aArticle history: Received 12 December 2018 // Accepted 6 May 2019 // Published online: 20 June 2019. Supplementary materials. Corresponding author: Casal, A.; Departamento de Produccion Animal y Pasturas, Facultad de Agronomia, Universidad de la Republica, Ruta 3 km 363, Paysandu, Uruguay; email:alcas@adinet.com.uy
520 $aABSTRACT. Oxidative stress occurs when oxidant production exceeds the antioxidant capacity to detoxify the reactive intermediates or to repair the resulting damage. Feed efficiency has been associated with mitochondrial function due to its impact on cell energy metabolism. However, mitochondria are also recognized as a major source of oxidants. The aim of this study was to determine lipid and protein oxidative stress markers, and gene and protein expression as well as activity of antioxidant enzymes in the liver of steers of divergent residual feed intake (RFI) phenotypes. Hereford steers (n = 111) were evaluated in post-weaning 70 days standard test for RFI. Eighteen steers exhibiting the greatest (n = 9; high-RFI) and the lowest (n = 9; low-RFI) RFI values were selected for this study. After the test, steers were managed together under grazing conditions until slaughter when they reached the slaughter body weight. At slaughter, hepatic samples were obtained, were snap-frozen in liquid nitrogen and stored at −80°C until analyses. Hepatic thiobarbituric acid reactive species and protein carbonyls were greater (P = 0.05) and hepatic 4-hydroxynonenal protein adducts tended (P = 0.10) to be greater for high- than low-RFI steers. Hepatic gene expression glutathione peroxidase 4, glutamate?cysteine ligase catalytic subunit and peroxiredoxin 5 mRNA was greater (P ≤ 0.05) and glutathione peroxidase 3 mRNA tended (P = 0.10) to be greater in low- than high-RFI steers. Hepatic protein expression and enzyme activity of manganese superoxide dismutase and glutathione peroxidase enzyme activity tended (P ≤ 0.10) to be greater for low- than high-RFI steers. High-efficiency steers (low-RFI) probably had better hepatic oxidative status which was strongly associated with greater antioxidant ability near to the oxidant production site and, therefore, reduced oxidative stress of the liver. Decreased hepatic oxidative stress would reduce maintenance requirements due to a lower protein and lipid turnover and better efficiency in the use of energy. © The Animal Consortium 2019
650 $aALIMENTACION ANIMAL
653 $aANTIOXIDANTS
653 $aENERGY METABOLISM
653 $aFEED EFFICIENCY
653 $aFEEDING
653 $aLIVER
653 $aOXIDATIVE STRESS
700 1 $aGARCÍA-ROCHE, M.
700 1 $aNAVAJAS, E.
700 1 $aCASSINA, A.
700 1 $aCARRIQUIRY, M
773 $tAnimal, 1 January 2020, Volume 14, Issue 1, Pages 78-85. Doi: https://doi.org/10.1017/S1751731119001332
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Registro original : |
INIA Las Brujas (LB) |
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Biblioteca
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Registro completo
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Biblioteca (s) : |
INIA Treinta y Tres. |
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Fecha actual : |
21/02/2014 |
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Actualizado : |
03/11/2014 |
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Tipo de producción científica : |
Actividades de Difusión |
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Autor : |
MORON, A.; QUINCKE, J.; CUADRO, W.; GIORELLO, D.; BERMUDEZ, R.; PRAVIA, V. |
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Afiliación : |
DAVID ALEJANDRO MORON YACOEL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN ANDRES QUINCKE WALDEN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; WASHINGTON ROBIN CUADRO LOPEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO GERMAN GIORELLO LEITES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAUL ENRIQUE BERMUDEZ COQUARD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIA VIRGINIA PRAVIA NIN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Red de fertilización de pasturas 2008-2011. |
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Fecha de publicación : |
2010 |
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Fuente / Imprenta : |
ln: Reunión técnica fertilización de pasturas, 2010 Durazno (Uruguay): INIA, 2010. |
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Páginas : |
p. 35-37 |
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Serie : |
(INIA Serie Actividades de Difusión ; 631) |
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Idioma : |
Español |
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Notas : |
INIA La Estanzuela |
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Thesagro : |
FERTILIZACION; PLANTAS FORRAJERAS; URUGUAY. |
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Asunto categoría : |
-- |
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Marc : |
LEADER 00681naa a2200241 a 4500
001 1031810
005 2014-11-03
008 2010 bl uuuu u00u1 u #d
100 1 $aMORON, A.
245 $aRed de fertilización de pasturas 2008-2011.
260 $c2010
300 $ap. 35-37
490 $a(INIA Serie Actividades de Difusión ; 631)
500 $aINIA La Estanzuela
650 $aFERTILIZACION
650 $aPLANTAS FORRAJERAS
650 $aURUGUAY
700 1 $aQUINCKE, J.
700 1 $aCUADRO, W.
700 1 $aGIORELLO, D.
700 1 $aBERMUDEZ, R.
700 1 $aPRAVIA, V.
773 $tln: Reunión técnica fertilización de pasturas, 2010 Durazno (Uruguay): INIA, 2010.
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INIA Treinta y Tres (TT) |
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